TERT-p mutations were also more frequent in tumors with a lower histologic grade (p = 0.036), lower mitotic activity (p = 0.001), absence of necrosis (p = 0.045), larger tumor size (p = 0.045), and absence of lymph node or distant metastasis (p = 0.020) (Table 3). This evidence concerns the gene TERT and neoplasm.