MAPT and supranuclear palsy, progressive, 1: Reflecting the heterogeneity of PSP tau pathology distribution, PSP patients can present with a variety of clinical presentation including frontotemporal dementia, spastic paraparesis, progressive apraxia if speech, corticobasal syndrome, primary gait failure with freezing, and a Parkinsonian-like syndrome that is initially responsive to levodopa therapy [1, 51].