High mast cell density has been related to tumor aggressiveness and reduced survivalSCF, NGF, C3a, IgE, C5a, IgG, IL4/5, TLR ligands, IFN‐γVEGF, FGF2, CCL‐2, Heparin, Histamine, TNFα, GM‐CSF, ANG‐1, tryptase, IL‐3/5/6/8/10/13. The gene discussed is C3; the disease is neoplasm.