Key role in the development and function of blood and lymph vessels. High vascular density at the CRC invasion front is reported to be directly associated with tumor recurrence, metastasis and patient mortality.PIGF, VEGF, PDGF, HIF‐1/2α, IL‐8, FGF, ANG1/2, TGFβVEGF, PDGFβ, HB‐EGF. This evidence concerns the gene CXCL8 and colorectal carcinoma.