Key role in the development and function of blood and lymph vessels. High vascular density at the CRC invasion front is reported to be directly associated with tumor recurrence, metastasis and patient mortality.PIGF, VEGF, PDGF, HIF‐1/2α, IL‐8, FGF, ANG1/2, TGFβVEGF, PDGFβ, HB‐EGF. Here, HBEGF is linked to neoplasm.