NK cells have a limited capacity to infiltrate the CRC microenvironment. NK and CD8+ T cells infiltration of the CRC microenvironment is reported to correlate with favorable prognosis.PRF1, TGFβ, kynurenines, NO, IL‐2/10/12/15/18Pro‐inflammatory cytokines, CRZ‐B, PRF1, IFN‐γ. Here, PRF1 is linked to colorectal carcinoma.