Moreover, similar to our previous finding of the significant decrease of plasma proinflammatory cytokines (IFN‐γ, IL‐6, and IL‐17A) in IL‐35‐treated lupus mice,3 we also found a significant decrease of proinflammatory cytokines (TNF‐α, IL‐6, and IL‐17A) and a significant increase of anti‐inflammatory cytokines (TGF‐β1 and IL‐10) in IL‐35p and Tregs treatments (Figure 6J). This evidence concerns the gene TNF and systemic lupus erythematosus.