In our study, upon the upregulated LAIR1 and downregulated PTPN11 (Figures 4D and 4E) and p‐STAT3 (Figure 4J) in IL‐35p‐treated mesangial cells in vitro, as well as the upregulated LAIR1 (Figures 5C and 5E) and downregulated p‐STAT3 (Figure 6C) in IL‐35‐treated lupus mice in vivo, we believe IL‐35‐upregulated LAIR1 may also transduce a negative signal by inhibiting PTPN11 to suppress STAT3 activation in mesangial cells. This evidence concerns the gene LAIR1 and systemic lupus erythematosus.