According to the bioinformatics analysis of proteome of collected urine sample, 105 DEPs among active JSLE‐LN patients (n = 10), inactive JSLE‐LN patients (n = 9) and healthy controls (n = 9) were found, in which several significantly up‐ (≥1.3 fold) and down‐ (≤0.77 fold) regulated interactive proteins like LAIR1, PDGFRβ, VTN, EPHB4, and EPHA4 were found through Venn and STRING analysis (Figures 1B–1D). This evidence concerns the gene EPHA4 and lobular neoplasia.