Combined with the increased positive staining of LAIR1 on mesangial cells of glomerulus in the IL‐35p and Tregs‐treated lupus mice (Figures 5C and 5E), and negative association among LAIR1+ glomerulus/kidney area with the parameters of LN (Figure 5E), The urine LAIR1 may become one of novel and potential diagnostic biomarkers for the development of JSLE‐LN. This evidence concerns the gene LAIR1 and systemic lupus erythematosus.