In this study, we can infer that IL‐35 (EBI3‐p35) and IL‐35R (IL‐12Rβ2‐gp130) may interact with JAK‐STAT‐PTPN11‐LAIR1 to affect JAK/STAT signaling pathway in alleviating inflammation of JSLE‐LN. Here, PTPN11 is linked to lobular neoplasia.