Although several studies indicated that LAIR1 could transduct the inhibitory signals through recruiting PTPN11 to inhibit the JAK/STAT signaling pathway in leukocytes,11, 12 the LAIR1 and PTPN11‐regulated signaling pathway and the inhibitory function of LAIR1 in mesangial cells of JSLE‐LN are still not well investigated. The gene discussed is PTPN11; the disease is lobular neoplasia.