Furthermore, we found a significant decreased scores of proteinuria, leukocyturia, and hematuria, as well as a decrement of renal histopathological scores including glomerulonephritis, interstitial nephritis, and vessels infiltration (Figures 5C and 5D), in contrast, a significant increased number of LAIR1+ mesangial cells in IL‐35p (***p < 0.001) and Tregs (###p < 0.001)‐treated lupus mice rather than IL‐35n and PBS treatments (Figures 5C and 5E). Here, LAIR1 is linked to glomerulonephritis.