Obtained results indicated that after 12 weeks of hyperglycemia, mice showed the same rate of diabetes‐induced CD68 positive cells infiltration in renal cortex (Figure S1), diabetic MacT3 mice showed increased TIMP3 mRNA expression (p < 0.05) (Figure 1B) and developed significantly less albuminuria compared with the diabetic wt mice (p < 0.05) (Figure 1C). Here, TIMP3 is linked to Hyperglycemia.