To address whether specific inhibition of ADAM17 in podocytes contributes to kidney protection during diabetes, we generated mice with a conditionally ablated Adam17 gene in podocytes by crossing mice carrying the floxed ADAM17 allele (Adam17flox/flox) with mice expressing the Cre expression cassette under the control of the Nphs2 promoter.28 Here, NPHS2 is linked to diabetes mellitus.