CD68 and obesity due to melanocortin 4 receptor deficiency: We have previously generated a mouse model with overexpression of human TIMP3 under the control of CD68 promoter, (MacT3), to restrict TIMP3 expression to cells of myeloid lineage,35 and have already shown that MacT3 mice are protected from obesity‐induced inflammation and the progression of vascular damage associated with atherosclerosis.