TIMP3 and diabetes mellitus: The loss of TIMP3 in animal models of diabetes leads to the exacerbation of diabetic renal injury in an organ‐specific manner as demonstrated by mesangial expansion and increased albuminuria, associated with inflammation, fibrosis, and increased levels of Nox4, whose role in the development of renal damage and fibrosis associated with diabetes has been well demonstrated by multiple studies.32, 33, 34