Mechanistically, our previous studies found that macrophage‐inducible C‐type lectin (Mincle) over‐activates Syk by sensing spliceosome‐associated protein 130 (SAP130) released from damaged intestinal epithelial cells during intestinal inflammation, and increased Syk phosphorylation is able to induce the production of inflammatory cytokines through NOD‐like receptor family pyrin domain containing 3 (NLRP3) inflammasome‐mediated macrophage pyroptosis, thus regulating intestinal mucosal immunity and promoting the disease progression of IBD.6, 12. The gene discussed is SAP130; the disease is inflammatory bowel disease.