Recently, high‐throughput sequencing data and etiology analysis revealed that ccRCC harbors well‐known mutations in a series of chromatin modifier genes, such as VHL, PBRM1, SETD2, and KDM5C. 4, 5Aberrant epigenetic programming has been recognized as a hallmark of renal cell carcinoma (RCC) tumorigenesis and progression.6 Here, KDM5C is linked to renal cell carcinoma.