Finally, we downloaded the Hi‐C data of RCC cells from the ENCODE dataset (https://www.encodeproject.org/) and integrated the JMJD6 and coactivator tracks, where these loops enable the physical interaction of the SE‐bound proteins N‐MYC and BRD4 with the promoter of VEGFA to facilitate transcription (Figure 6L). This evidence concerns the gene MYCN and renal cell carcinoma.