To confirm the above p300/JMJD6 axis and JMJD6 downstream targets in clinical samples, we detected the expression levels of p300, JMJD6, and representative JMJD6‐driving targets (VEGFA and β‐catenin) using the RCC tissue microarrays from Ruijin Hospital. The gene discussed is EP300; the disease is renal cell carcinoma.