We found that knockdown of PLAGL2 significantly abrogated miR‐378a‐3p antagonism‐induced enhancement of β‐catenin signaling in SMMC‐7721 tumor cells (p < 0.01) (Figures 9I and 9J), suggesting that miR‐378a‐3p reduction‐triggered upregulation of PLAGL2 is functionally important for activation of β‐catenin in HCC cells. The gene discussed is PLAGL2; the disease is neoplasm.