ESR1 and cancer: For instance, the impairment of clathrin‐mediated endocytosis via cytoskeletal change by epithelial to fibroblastoid conversion is associated with the des‐gamma‐carboxy prothrombin production in HCC39; Hepatocyte growth factor stimulates the formation and migration of HCC cells40, 41; Estrogen receptor signaling plays an important role in the induction of HCC42; LPS‐TLR4 signaling promotes cancer cell survival and proliferation by regulating the activity of the MAPK signaling pathway.43