RT‐qPCR (Figure 8F) and western blot (Figures 8G and 8H) analyses further showed that overexpression of miR‐378a‐3p with agomiR‐378a‐3p downregulated both the mRNA and protein levels of PLAGL2 in MHCC97H tumor cells, whereas inhibition of miR‐378a‐3p with antagomiR‐378a‐3p upregulated the levels of PLAGL2 in SMMC‐7721 tumor cells (p < 0.01). The gene discussed is PLAGL2; the disease is neoplasm.