To check whether β‐catenin is involved in miR‐378a‐3p‐elicited functional effects in HCC, we further analyzed the effect of blocking β‐catenin signaling via siRNA‐mediated knockdown of TCF4 or LEF1 (Figure 9E) on the proliferative, migratory, and invasive capacity of SMMC‐7721‐antagomiR‐378a‐3p tumor cells. Here, TCF4 is linked to hepatocellular carcinoma.