PLAGL2 and hepatocellular carcinoma: To address whether miR‐378a‐3p‐mediated PLAGL2 downregulation would lead to inactivation of β‐catenin signaling in human HCC cells, we analyzed the expression, subcellular location, and transcriptional activity of β‐catenin by western blot, confocal microscopy, and luciferase reporter analysis, respectively.