Likewise, the UMNs of hSOD1G93A and the prpTDP‐43A315T mice, which were developed to mimic mSOD1 toxicity and TDP‐43 pathology mediated motor neuron degeneration in patients,58, 59 develop progressive UMN loss34, 57, 60 and display similar defects at a cellular level. The gene discussed is TARDBP; the disease is Motor neuron atrophy.