Although the two MYOF inhibitors have comparable anti‐invasion activities (Figure 1C), evidences from the binding affinity assay (Figure 1C) and target identification experiments (Figure S10) suggested that WJ460 may have other important targets in addition to MYOF, while YQ456 has a higher targeting specificity to MYOF in colorectal cancer cells. This evidence concerns the gene MYOF and colorectal cancer.