The vaccine efficacy could be improved by providing additional immunostimulatory signals through alloreactive T cells secreting high levels of T‐cell activating cytokines, helping to induce allo‐ and auto‐antibodies, enhancing the cross‐priming of antigen‐presenting cells (APCs) for CD8+ T cells responding to tumour antigens.78, 79, 80, 81, 82, 83. Here, CD8A is linked to neoplasm.