Long et al. constructed prognostic and diagnostic models consisting of two DNA methylation-driven genes (SPP1 and LCAT) [65] and Lu et al. showed that a combination of multiple methylation markers (APC, COX2, RASSF1A and miR-203) could accurately identify hepatitis B virus (HBV)-related HCC from patient plasma samples and exhibited diagnostic and prognostic potential [66], but the inclusion and exclusion criteria of HCC patients were not reported in these two papers. The gene discussed is SPP1; the disease is hepatocellular carcinoma.