To build an individualized predictive model for HCC based on the four SR-CDMGs, a risk score for each patient in the TCGA dataset was computed by summing the methylation levels multiplied by the corresponding coefficients from the LASSO Cox analysis: risk score = (0.01489826 × methylation level of WDR69) + (0.15868618 × methylation level of HOXB4) + (0.16674959 × methylation level of CDKL2) + (0.16689301 × methylation level of HOXA10). The gene discussed is HOXB4; the disease is hepatocellular carcinoma.