In terms of diagnostic prediction models, Cheng et al. identified six HCC-specific hyper-methylated sites (NEBL [cg23565942], FAM55C [cg21908638, cg11223367 and cg03509671], GALNT3 [cg05569109], and DSE [cg11481534]) as potential diagnostic biomarkers, and the combination of these six sites showed a high sensitivity and a high specificity for the diagnosis of HCC [59]. This evidence concerns the gene DSE and hepatocellular carcinoma.