36 G > C; p. Ser12Cys) detected previously in Branch A could not account for the disease phenotype in both branches of the kindred, we note that mice homozygous null for Gad1 die at birth with cleft palate and hypoxia, with omphalocele in about 50% (Asada et al., 1997; Condie et al., 1997; Saito et al., 2010). This evidence concerns the gene GAD1 and omphalocele.