Genetic studies have revealed that variants in PSCK9 (proprotein convertase subtilisin/kexin type 9), HMGCR (HMG-coenzyme A reductase), and NPC1L1 (Niemann-Pick C1-like intracellular cholesterol transporter 1) are correlated with decreasing LDL-C levels and low CAD risk (21–23). The gene discussed is HMGCR; the disease is coronary artery disorder.