Disorders which feature LM, including overgrowth syndromes such as congenital lipomatous overgrowth with vascular, epidermal and skeletal anomalies (CLOVES) and Klippel-Trénaunay syndrome (KTS), are also frequently associated with somatic mutations in the PIK3CA gene (22) (Figure 2). This evidence concerns the gene PIK3CA and lymphangioma.