Manipulated upregulation of circFGFR1 promotes the proliferation, invasion, migration, and immune evasion of NSCLC cells, while knockdown of CXCR4 resensitizes NSCLC cells to anti-PD-1 immunotherapy (Zhang P. et al., 2019). The gene discussed is CXCR4; the disease is non-small cell lung carcinoma.