Pre-clinical model of SCC development is also accompanied by infiltration of Tregs in the skin and draining lymph nodes (LN), and depletion of these cells using anti-CD25 significantly impaired SCC progression by increasing the infiltration of activated CD4+ and CD8+ T cells in the TME and the production of anti-tumor cytokines such as IL-12 and IFN-γ (Ramos et al., 2012). Here, CD4 is linked to neoplasm.