CAFs also have a role in immunosurveillance and tumor escape via CD276 (B7-H3), which augments Tregs and inhibit cytotoxic CD8+ T cell responses (Ji et al., 2020) and promote tumor development by enhancing monocyte chemoattractant protein-1 (MCP-1)–dependent macrophage infiltration and chronic inflammation (Zhang et al., 2011; Figure 1B). This evidence concerns the gene CCL2 and neoplasm.