TMPRSS2 and cancer: Overexpression of TMPRSS2:ERG was found to induce the expression of the osteoblastic markers Collagen Type I Alpha 1 Chain (COL1A1) and Endothelin-1 (ET-1), responsible for improved acquisition of a bone-like phenotype in cancer cells (osteomimicry), helping the cancer cells survive in the bone microenvironment (Delliaux et al., 2018).