For example, Shh activity drives orofacial morphogenesis (Lan and Jiang, 2009; Kurosaka, 2015), while targeted pathway disruption results in orofacial clefts (OFCs) of the lip and palate in animal models (Lipinski et al., 2010; Heyne et al., 2015a). Here, SHH is linked to orofacial cleft.