Studies by Holla et al. (2011) suggest that the molecular cross talk between PGE2 and NR4A2 is central to controlling CRC survival mediated through the regulation of apoptosis by blocking cleavage of caspase-3, with NR4A2 playing a central role as a point of transcriptional integration coupling eicosanoid and metabolic pathways. This evidence concerns the gene NR4A2 and colorectal carcinoma.