TGFB1 and breast cancer: Constitutive migration and TGFβ-induced migration of breast cancer cells are reliant on nuclear and extranuclear expression of NR4A1, respectively, and it has been shown that selective NR4A1 antagonists inhibit both pathways by decreasing the NR4A1-dependent expression of β1-integrin, inhibit TGFβ-induced nuclear export of NR4A1, and induced EMT (Hedrick et al., 2016).