Concurrently, miR-128-3p-overexpressing exosomes induced the activation of TGF-β/SMAD (Figure 8F) and JAK/STAT3 (Figure 8G) in tumor tissues, but exosomes isolated from miR-128-3p-silenced HCT-116 cells (si-miR-128-3p-Exo) inhibited tumor growth, likely by enhancing the expression FOXO4. This evidence concerns the gene TGFB1 and neoplasm.