STAT3 and colorectal neoplasm: In addition, inflammatory factors can promote tumor growth and induce EMT in a variety of malignancies, including breast, liver, head and neck, and colorectal tumors via the regulation of Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) and TGF-β signaling (Sehgal, 2010; Crusz and Balkwill, 2015).