AGT and renal fibrosis: To elucidate the regulatory function of TRIM6 in renal fibrosis, we treated HK2 proximal tubule epithelial cells with Angiotensin II (Ang II), which induces EMT and ER stress during the progression of chronic kidney damage, eventually contributing to renal fibrosis (Carlisle et al., 2012; Lavoz et al., 2012).