Several members of the TRIM protein have been implicated in renal fibrosis-related pathways (Liu, 2011; Nogueira et al., 2017), such as TGF-β1/Smads (Lee, 2018), PDGF (Wang et al., 2020), and Wnt/β-catenin (Yang et al., 2017). This evidence concerns the gene TRAT1 and renal fibrosis.