TSC2 and renal fibrosis: Given the roles of TRIM6, TSC1, TSC2, and nuclear NF-κB p50 in renal fibrosis, we explored the relationships between the levels of TRIM6, TSC1, TSC1, and nuclear NF-κB p50 and severity of renal fibrosis based on the estimated IF/TA scorein patients suffering from renal fibrosis of different severities (Figure 7).