Particularly for cervical cancer, E6 interacts with the LXLL motif of E6-associated protein (E6AP), an E3 ubiquitin ligase that works as a connecting bridge between E6 and p53 (Figure 3), inducing p53 degradation through the proteasome pathway and consequently blocking the p53-dependent apoptosis Bcl2 family. This evidence concerns the gene TP53 and cervical cancer.