The persistent infection by high-risk HPV types, the E6 and E7 viral oncoproteins, is due to their impact on apoptosis/senescence and proliferation via inactivation of p53 and pRb, contributing to cervical epithelial transformation in cancer (reviewed by Ghittoni et al., 2015; reviewed by Hoppe-Seyler et al., 2018). This evidence concerns the gene RB1 and cancer.