The results showed that CTIF and GNL1 were potential protective genes and ANG, APOBEC3F, CARHSP1, FBXO17, ISG20, KHNYN, LSM12, PABPC3, PNRC2, RDM1, SPATS2L, and TTF2 might act as risk factors in glioma patients. Here, PABPC3 is linked to central nervous system cancer.