Reporter assay revealed that insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2/IMP2) is a type 2 diabetes- and obesity-associated gene that suppresses Ucp1 mRNA translation likely via both 5′- and 3′-UTRs. The gene discussed is IGF2BP2; the disease is obesity due to melanocortin 4 receptor deficiency.