While the expression of dopamine receptors shows a characteristic pattern in neuronal cells, targeting dopamine receptors such as D2R (Simanjuntak et al., 2014; Ho et al., 2017) and D4R (Smith et al., 2014) is believed to have an anti-dengue effect, preventing infection as well as protecting against neurotoxicity in the CNS. This evidence concerns the gene DRD2 and dengue disease.