Interestingly, treatment of these cells with cisplatin in combination with Staurosporine (natural broad-spectrum antitumor agent derived from Streptomyces staurosporeus (142–144) abrogates the up-regulation of p62, suggesting that Staurosporine sensitizes cancer cells to cisplatin in a p62-dependent manner (139). This evidence concerns the gene SQSTM1 and cancer.