As shown in Table 2, RING1 protein expression significantly and negatively correlated with tumor size (P = 0.029), LNM (P = 0.017), TNM stage (P = 0.016), ER (P = 0.005), Ki67 (P = 0.015), and P53 status (P = 0.034). The gene discussed is TP53; the disease is neoplasm.