In light of our results that showed that RING1 protein expression significantly and negatively correlates with tumor size, LNM, TNM stage, ER, Ki67, and P53 status (Table 2), it is adequate to suggest that RING1 plays a key role in promoting breast cancer cells’ growth and metastasis, though the activation of p53 protein expression. The gene discussed is ESR1; the disease is breast carcinoma.