The immunoregulatory molecules cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed death receptor 1 (PD-1), and programmed death ligand 1 (PD-L1) were also higher in high IL-33 tumor samples than in low IL-33 tumor samples (Figure 2B, Supplementary Table S2). The gene discussed is CTLA4; the disease is neoplasm.