Several of these are directly associated with AD (GSK3B,IL1B,MAPK3/8/10/14,WNT1,WNT3A,KAT5 NOTCH1 andTNF), Tau (GSK3B andCLU) and amyloid (CD36,NLRP3,CLU,FOXO3,PARP1,PRNP). This evidence concerns the gene NOTCH1 and Alzheimer disease.