The significant pathways associated with the AD-DS geneset are related to neurodegenerative disorders (AD P=3.1E-23, Parkinson’s disease (P=1.39E-04) and Huntington’s disease P=1.36E-07) as well as many signaling pathways linked to insulin (P=1.86E-09) and inflammation (Jak/Stat P=9.49E-04), Toll receptor (P=4.04E-10), Interferon-gamma signaling (P=8.90E-06). This evidence concerns the gene INS and Alzheimer disease.