It has been previously shown that the activation of NOD1 promotes colon cancer metastases (Jiang et al., 2020); inhibition of RIPK2 can delay NOD signaling to decrease the production of inflammatory cytokine (Nachbur et al., 2015), so RIPK2 could regulate the NOD signaling to control the occurrence and development of inflammation-related tumors. The gene discussed is RIPK2; the disease is malignant colon neoplasm.