RIPK2 and cancer: The mRNA expression of RIPK2 was highly overexpressed in GC tissues compared to that in the normal gastric tissues based on TCGA-stomach tumor database (Figures 2A,B) (A: 375 GC tissues, 32 normal gastric tissues; B: 28 GC tissues and paired non-tumor tissues) and GEO (Figure 2C) (GSE19826: 12 GC tissues, 12 matched non-cancer gastric tissues; GSE79973: 10 GC tissues and paired adjacent tissues; GSE 33335: 25 GC and 25 normal gastric tissues).