INS and esophageal squamous cell carcinoma: KCNJ15 is known to participate in insulin secretion (Okamoto et al., 2012), nervous system diseases (Zhou et al., 2018), gastric acid secretion (Yuan et al., 2015), kidney cancer (Liu et al., 2019), and esophageal squamous cell carcinoma (Nakamura et al., 2020).