This recruitment of pro-inflammatory cells, which significantly changes the immune cell composition of the liver during NAFLD, may occur via various chemoattractant-axes, including the CCL2/CCR2, CCL1/CCR8, CXCR6/CXCL16, and CCL25/CCR9-pathways, with the chemoattractants being secreted by activated Kupffer cells, liver sinusoidal endothelial cells, and hepatic stellate cells. The gene discussed is CCL2; the disease is metabolic dysfunction-associated steatotic liver disease.