Furthermore, ablation of histone H3K4 demethylase LSD1 resulted in upregulation of ERVs and accumulation of dsRNAs that are recognized by MDA5 and TLR3 in cancer cells, which promotes anti-tumor T cell immunity and elicits significant responses to anti-PD-1 therapy in a mouse melanoma model (238). This evidence concerns the gene KDM1A and cancer.