Accordingly, most of CD8 TRM cells express CXCR3 in vitiligo, indicating inclusion of the population of melanocyte-specific CD8 T cells, which display increased production of IFN-γ and tumor necrosis factor-α with moderate cytotoxic activity (143). Autoreactive TRM cells are also present in mouse models of vitiligo. This evidence concerns the gene CD8A and vitiligo.