In line with this, a relatively high frequency of Tfh cells co-expressing CXCR5 and CXCL13 was found in AITL compared to tonsils, suggesting an important role for the CXCR5/CXCl13 axis as regulator of the Tfh cell trafficking and positioning in AITL LNs. This evidence concerns the gene CXCL13 and angioimmunoblastic T-cell lymphoma.