However, there were no differences concerning age, BMI, disease duration, IGM, serum cortisol, plasma ACTH, the percentage of hypertension, post-surgery growth hormone deficiency (GHD), post-surgery hypogonadotropic hypogonadism (HH), and hydrocortisone replacement therapy (HRT) between the two groups. This evidence concerns the gene POMC and hypogonadotropic hypogonadism.