We sequenced a total of 200 diagnosed diabetes subjects in this study and found significant differences among the 3 groups (Figure 1), such as age (P = 2.60 × 10-8, Kruskal-Wallis test) fasting plasma glucose (FPG) (P = 0.00028, Kruskal-Wallis test), fasting plasma C-peptide (FPGC-peptide) (P = 2.80 × 10-7, Kruskal-Wallis test), insulin (P = 0.0023, Kruskal-Wallis test), HbA1c (P = 0.0015, Kruskal-Wallis test), and body mass index (BMI) (P = 0.0079, Kruskal-Wallis test). Here, INS is linked to diabetes mellitus.