In serial blood samples collected at 3, 6, 12, 18, 24, 48, 72, 96, and 120 h after onset of stroke symptoms, NSE concentration, measured by immune-assay, rose in the first 2–3 h, then fell until 12 h before a second elevation that was maintained until measurement ended on day 5. The gene discussed is ENO2; the disease is stroke disorder.