In DSS-induced UC models, Wu et al. (2020) reported that nuclear receptor binding factor 2 (NRBF2), a regulatory subunit of the autophagy-related Beclin-1-ATG14-VPS15-VSP34 complex, was necessary for the clearance of apoptotic cells and inflammation suppression during DSS-induced colitis. Here, NRBF2 is linked to colitis.