Besides NOD2, IRGM, ULK-1, and XBP-1, it was recently reviewed by us that the mutation or deletion of some other autophagy-related genes, including ATG4, transcription factor 4 (TCF4), leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2), and ATG5 in Paneth cells, were related to the pathogenesis of IBD, especially CD (Wang et al., 2018c). Here, TCF4 is linked to inflammatory bowel disease.