ATG16L1 and Cowden disease: In addition, some single nucleotide polymorphisms (SNPs) of ATG16L1, such as rs2241880 and rs6754677, have been detected in CD patients and shown to be associated with CD onset (Baradaran Ghavami et al., 2019; Buisson et al., 2019; Kee et al., 2020; Tsianos et al., 2020; Varma et al., 2020).