In this study, the aortic vascular endothelia of Wistar rats and SHRs was selected for trial, and the results showed that the levels of NLRP3 and caspase-1 in SHRs were significantly increased, and when the NLRP3 inflammasome was clearly activated in hypertension, the downstream inflammatory factors such as IL-1β and IL-18 were also augmented. The gene discussed is IL18; the disease is hypertensive disorder.