In fact, since TLR5 modulation might play a protective role against respiratory infection, it has been hypothesized that the TLR5 immunomodulation might reduce cytokine storm production and restore the altered immune response following SARS-CoV-2 infection, even if this hypothesis has to be fully investigated (Chakraborty et al., 2020). This evidence concerns the gene TLR5 and respiratory tract infectious disorder.