Consistent with this view, previous reports have shown that Anoctamin1 (ANO1), the calcium-activated chloride channel, positive cells are maintained in ICC-SMP, but decreased in ICC-MP and ICC-IM whether they are c-Kit or Ano1-positive in W/Wv mouse colon (Wang et al., 2014). The gene discussed is ANO1; the disease is intrahepatic cholangiocarcinoma.