In this line, mutations in LAMP2 gene promoter itself have been also associated with sporadic PD patients (Pang et al., 2012), and there is a decrease in LAMP2A and HSC70 expression in the substantia nigra and amygdala of PD brains compared to control samples (Alvarez-Erviti et al., 2010). This evidence concerns the gene LAMP2 and Parkinson disease.