HSPA8 and Parkinson disease: Moreover, inductors of PD animal models such as 6-hydroxydopamine (6-OHDA) and rotenone, or even methamphetamine exposure, alter the expression of both Lamp2a and Hsc70, leading to neurotoxicity caused by α-synuclein accumulation (Gao et al., 2014; Sala et al., 2016; Wang et al., 2018b; Sun et al., 2019).