Furthermore, we measured OXT mRNA from the amygdala, hypothalamus and hippocampus; the results showed that there was no difference on OXT expression in both the amygdala and hippocampus across all treatments, while OXT expression was significantly decreased in the maternal diabetes (STZ/P-VEH) group compared to the control (CTL/P-VEH) group in the hypothalamus, and increasing postnatal expression of either OXTR or ERβ had no effect (see Supplementary Figure 5c). The gene discussed is OXTR; the disease is diabetes mellitus.