The results showed that gene expression of SOD2, ERβ and OXTR were significantly decreased in the maternal diabetes (STZ/WT) group compared to the control (CTL/WT) group; OXTR knockout (OXTR–/–) mice significantly decreased OXTR expression, but showed no effect on the expression of SOD2 and ERβ in either the control (CTL/OXTR–/–) or diabetic (STZ/OXTR–/–) groups (see Figures 3A–C and Supplementary Figure 1c). This evidence concerns the gene OXTR and diabetes mellitus.