The results showed that ERβ lentivirus manipulation was successful and that ERβ expression completely reversed, while ERβ knockdown mimicked hyperglycemia [HG(4d) + LG(4d)/CTL group]-induced OXTR suppression, compared to the LG(4d) + LG(4d)/CTL control group (see Figures 2G–I and Supplementary Figure 1b). This evidence concerns the gene ESR2 and Hyperglycemia.