The results showed that mice from the maternal diabetic (STZ/P-VEH) group buried significantly fewer marbles (see Figure 6A) and spent less time in the Open Arm while spent more time in the Closed Arm in EPM tests (see Figure 6B) compared to the control (CTL/P-VEH) group; amygdala infusion of either OXTR (STZ/P-↑OXTR) or ERβ (STZ/P-↑ERβ) completely reversed the maternal diabetes-mediated effect. This evidence concerns the gene OXTR and diabetes mellitus.