It has been reported that genetic and epigenetic change-mediated OXTR deficiency is associated with ASD (Gregory et al., 2009), and DNA methylation (Behnia et al., 2015; Maud et al., 2018; Puglia et al., 2018) on the OXTR promoter contributes to OXTR deficiency and subsequent social deficits (Puglia et al., 2015, 2018). This evidence concerns the gene OXTR and hyperinsulinemic hypoglycemia, familial, 4.