ESR2 and diabetes mellitus: Furthermore, mice from this group spent significantly more time in the Empty side for sociability (see Figure 6E) and less time for social novelty (see Figure 6F) in the three-chambered social tests compared to the control (CTL/P-VEH) group; amygdala infusion of OXTR (STZ/P-↑OXTR) showed no effect, while amygdala infusion of ERβ (STZ/P-↑ERβ) completely reversed the maternal diabetes-mediated effect.