The results showed that gene expression of SOD2, ERβ and OXTR was significantly decreased in the maternal diabetes (STZ/P-VEH) group compared to the control (CTL/P-VEH) group; increasing postnatal expression of OXTR (STZ/P-↑OXTR) had no effect on SOD2 and ERβ, while increasing postnatal expression of ERβ (STZ/P-↑ERβ) completely reversed maternal diabetes-mediated gene suppression of SOD2 and OXTR (see Figures 5A–C and Supplementary Figure 1d). Here, ESR2 is linked to diabetes mellitus.