Unregulated levels of IRF3 and the type-IFNs have been implicated in tumorigenesis and progression of autoimmune disorders including rheumatoid arthritis (RA), SLE and primary Sjogren’s syndrome (Gottenberg et al., 2006; Crow, 2014; Muvaffak et al., 2014; Jiao et al., 2018; Barrat et al., 2019; Petro, 2020). Here, IRF3 is linked to rheumatoid arthritis.