STING1 and STING-associated vasculopathy with onset in infancy: This gain of function mutation enhanced the ability of STING to dimerise in the absence of cGAMP, resulting in constitutive IFN activation (König et al., 2017); de novo germline mutations in STING have been identified in SAVI patients, causing a hypersensitivity to ligand activation in STING, resulting in constitutive production of type-I IFNs (Liu et al., 2014).