Lymphocyte-activation gene 3 (LAG-3) is mainly expressed on activated T cells as an inhibitory receptor and is significantly upregulated, together with other inhibitory receptors such as PD-1, TIGIT, TIM3, and CD160, in many types of cancer, which induces the exhaustion of T cells in malignant tumors [6–9]. This evidence concerns the gene HAVCR2 and cancer.