Although exercise stimulates muscle glucose uptake mainly by translocation of active GLUT-4 to the outer cell membranes, other reactions and processes such as inhibition of insulin release, increased secretion of glucagon, catecholamines and cortisol leading to hepatic gluconeogenesis and glycogenolysis in muscles and liver prevent hypoglycemia and even can moderately increase glucose levels37,47. This evidence concerns the gene INS and Hypoglycemia.