In hypertension, higher blood pressure via vasoactive peptides including endothelin 1 and angiotensin II results in peripheral arterioles vasoconstriction, smooth muscle cells apoptosis, and vascular fibrosis, resulting in remodeling66–68, e.g., inward eutrophic remodeling and outward hypertrophic remodeling69. The gene discussed is AGT; the disease is hypertensive disorder.