Although GEMMs, such as the KPC (LSL-KrasG12D/+; LSL-Trp53R172H/+; Pdx-1-Cre) mouse model30, are excellent; verifying the relationships between the origin and heterogeneity of CAFs in those mice is difficult as well as clinical pancreatic cancer. The gene discussed is PDX1; the disease is familial pancreatic carcinoma.